Сотрудники

Паширова Татьяна Никандровна / Tatiana Pashirova

Лаборатория фосфорсодержащих аналогов природных соединений / Laboratory of phosphorus-containing analogues of natural compounds / старший научный сотрудник / senior researcher

Степень
кандидат химических наук / PhD in Physical Chemistry

Специальность ВАК
02.00.04 – Физическая химия (2005 год)

Комната №: Room № 307

Email: pashirova@iopc.ru, tatyana_pashirova@mail.ru

Contact information:
Address: Room № 307, 8 Arbuzov str., Kazan, 420088, Russian Federation
E-mail: tatyana_pashirova@mail.ru, pashirova@iopc.ru,
Tel: (007) 843 272 73 84, fax: (007) 843 273 22 53

Research interests: supramolecular chemistry, drug delivery systems, solid lipid nanoparticles, liposomes, nanoreactors, colloidal systems, micellar catalysis.

Position

• 2001-2023 Senior research fellow of the A.E. Arbuzov Institute of Organic and Physical Chemistry of the Russian Academy of Sciences, Kazan, Russian Federation

Education

• 2012 Post-Doctoral Scholar at the Faculty of Health Sciences of University Fernando Pessoa, Portugal, Health Doctorate Program in the area of Biopharmaceutical Chemistry under the supervision of the Prof. Eliana B. Souto on Lipid nanoparticulates for hydrophylic peptides
• 2001-2005 Ph.D. in Physical Chemistry, PhD Thesis entitled: ‘Supramolecular catalytic systems based on derivatives calix[4]resorcinarenes, phenols, their metalcomplexes and surfactants’ (A.E. Arbuzov Institute of Organic and Physical Chemistry of the Russian Academy of Sciences, Kazan, Russian Federation
• 1999-2001 Master`s Degree, Kazan State Technological University, Faculty of Chemical Engineering and Technology, Kazan, Russian Federation
• 1995-1999 Bachelor`s Degree, Kazan State Technological University, Faculty of Chemical Engineering and Technology, Kazan, Russian Federation

Additional education

• 1999-2001 Pedagogy, Kazan State Technological University, Kazan, Russian Federation

Publications: The full list of publication consists of 113 articles and more than 100 conference proceedings.

Chapters in books:

1. Pashirova T.N., Afonso A.B., Terekhova N.V., Kamalov M.I., Masson P., Souto E.B., Chapter Nanogels for drug delivery: physicochemical properties, biological behavior, and in vivo applications in book Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications, Ed. Santana M.H., Souto E.B., Shegokar R., Academic Press, 2023, Elsevier Inc., P.95-131. ISBN: 978-0-323-90471-1, doi: https://doi.org/10.1016/B978-0-323-90471-1.00005-0.
2. Pashirova T.N., Fernandes A.R., Sanchez-Lopez E., Garcia M.L., Silva A.M., Zakharova L.Ya., Souto E.B., Chapter 5 - Polymer nanogels: Fabrication, structural behavior, and biological applications, in Theory and Applications of Nonparenteral Nanomedicines, Academic Press, 2021, Pages 97-111. doi: https://doi.org/10.1016/B978-0-12-820466-5.00005-3
3. Zakharova L.Y., Pashirova T.N., Fernandes A.R., Doktorovova S., Martins-Gomes C., Silva A.M., Souto E.B., Chapter 14: Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology, in Organic Materials as Smart Nanocarriers for Drug Delivery, Ed. A.M. Grumezescu, 2018, Elsevier, 601-618. doi: https://doi.org/10.1016/B978-0-12-813663-8.00014-2
4. Zakharova L., Pashirova T., Kashapov R., Gabdrakhmanov D., Sinyashin O., Chapter 24: Drug delivery mediated by confined nanosystems: structure-activity relations and factors responsible for the efficacy of formulations, in Nanostructures for Drug Delivery, Eds. E. Andronescu, A. Grumezescu, 2017, William Andrew, 749-806. doi:https://doi.org/10.1016/B978-0-323-46143-6.00024-5.
5. Zakharova L., Mirgorodskaya A., Gaynanova G., Kashapov R., Pashirova T., Vasilieva E., Zuev Y., Synyashin O., Supramolecular strategy of the encapsulation of low molecular weight food ingredients, in Encapsulations, Ed. A.M. Grumezescu, 2016, Academic Press, 924, 295-362. doiI:10.1016/B978-0-12-804307-3.00008-9.

Reviews:

1. Pashirovа T.N., Bogdanov A., Masson P. Therapeutic nanoreactors for detoxification of xenobiotics: Concepts, challenges and biotechnological trends with special emphasis to organophosphate bioscavenging, Chem. Biol. Interact., 2021, 346, 109577, doi: 10.1016/j.cbi.2021.109577.
2. Bjerk T.R, Severino P., Jain S., Marques C., Silva A.M, Pashirova T., Souto E.B, Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology, Bioengineering (Basel). 2021, 8(8), 115, doi: 10.3390/bioengineering8080115
3. Zakharova L.Y., Pashirova T.N., Doktorovova S., Fernandes A.R., Sanchez-Lopez E., Silva A.M., Souto S.B., Souto E.B., Cationic surfactants: self-Assembly, structure-activity correlation and their biological applications, Int. J. Mol. Sci. 2019, 20(22). pii: E5534. doi: 10.3390/ijms20225534.
4. Souto E.B., Souto S.B., Campos J.R., Severino P., Pashirova T.N., Zakharova L.Y., Silva A.M., Durazzo A., Lucarini M., Izzo A.A., Santini A., Nanoparticle delivery systems in the treatment of diabetes complications, Molecules, 2019, 24, 4209. doi: 10.3390/molecules24234209.
5. Zakharova L.Ya., Kashapov R.R., Pashirova T.N., Mirgorodskaya A.B., Sinyashin O.G, Self-assembly strategy for the design of soft nanocontainers with controlled properties, Mendeleev Commun., 2016, V.26, №6, 457-468. doi: https://doi.org/10.1016/j.mencom.2016.11.001.

Patents:

• Liposomal form of Abies Sibirica resin for non-invasive delivery of the biologically active substance of Abies Sibirica oleoresin to brain, which has antioxidant, cytotoxic activity against cervical cancer cells, and method for its production, Sinyashin K.O., Zakharova L.Ya., Pashirova T.N., Petrov K.A., Voloshina A.D., Vyshtakalyuk A.B., Rizvanov I.Kh., Babaev V.M., Maganova F.I. Patent № RU 2757873 C2, 22.10.2021. Application № 2019139529 from 03.12.2019.

Articles (last 5 years):

2022

1. Pashirova T.N., Shaihutdinova Z., Mansurova M., Kazakova R., Shambazova D., Bogdanov A., Tatarinov D., Daudé D., Jacquet P., Chabrière E., Masson P. Enzyme Nanoreactor for In Vivo Detoxification of Organophosphates, ACS Appl Mater Interfaces, 2022, 14(17), 19241-19252, doi: 10.1021/acsami.2c03210.
2. Pashirova T.N., Shaihutdinova Z.M., Vandyukov A.E., Lyubina A.P., Amerhanova S.K., Voloshina A.D., Samorodov A.V., Souto E.B., Mironov V.F., Bogdanov A.V., Synthesis and structure-activity-toxicity relationships of DABCO-containing ammonium amphiphiles based on natural isatin scaffold, J. Mol. Liq., 2022, 365, 120217. doi: 10.1016/j.molliq.2022.120217.
3. Shaihutdinova Z., Pashirova T.N., Masson P. Kinetic Processes in Enzymatic Nanoreactors for In Vivo Detoxification, Biomedicines, 2022, 10(4), 784, doi: 10.3390/biomedicines10040784.

2021

1. Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: synthesis, structure, and biological properties, Molecules, 2021, 26(21), 6350. doi: 10.3390/molecules26216350

2020

1. Pashirova T.N., Sapunova A.S., Lukashenko S.S., Burilova E.A., Lubina A.P., Shaihutdinova Z.M., Gerasimova T.P., Kovalenko V.I., Voloshina A.D., Souto E.B., Zakharova L.Ya, Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations, Int J Pharm, 2020, 575, 118953. doi: 10.1016/j.ijpharm.2019.118953.
2. Burilova E.A, Pashirova T.N, Zueva I.V, Gibadullina EM, Lushchekina SV, Sapunova AS, Kayumova RM, Rogov AM, Evtjugin VG, Sudakov IA, Vyshtakalyuk AB, Voloshina AD, Bukharov SV, Burilov AR, Petrov K.A, Zakharova L.Ya, Sinyashin O.G., Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer's disease via an intranasal route, Nanoscale, 2020, 12(25), 13757-13770. doi: 10.1039/d0nr04037a.
3. Buzyurova D.N., Pashirova T.N., Zueva I.V., Burilova E.A., Shaihutdinova Z.M., Rizvanov I.Kh., Babaev V.M., Petrov K.A., Souto E.B. Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat, Toxicology, 2020, 444, 152578, doi:10.1016/j.tox.2020.152578.
4. Pashirova T.N., Fetin P.A., Lezov A.A., Kadnikov M.V., Valeeva F.G., Burilova E.A., Bilibin A.Yu., Zorin I.M., Self‐Assembled Quaternary Ammonium‐Containing Comb‐Like Polyelectrolytes for the Hydrolysis of Organophosphorous Esters: Effect of Head Groups and Counter‐Ions, ChemPlusChem, 2020, 85, 8, 1939-1948, doi: 10.1002/cplu.202000417.
5. do Nascimento M.F, Cardoso J.C., Santos T.S., Tavares L.A., Pashirova T.N., Severino P., Souto E.B., de Albuquerque-Junior R.L.C., Development and characterization of biointeractive gelatin wound dressing based on extract of punica granatum linn, Pharmaceutics, 2020, 12, 1204; doi:10.3390/pharmaceutics12121204.
6. Terekhova N.V., Tatarinov D.A., Shaihutdinova Z.M., Pashirova T.N., Lyubina A.P., Voloshina A.D., Sapunova A.S., Zakharova L.Ya, Mironov V.F, Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action, Bioorg. Med. Chem. Lett., 2020, 30(13), 127234. doi:10.1016/j.bmcl.2020.127234.

2019

1. Pashirova T.N., Burilova E.A., Tagasheva R.G., Zueva I.V., Gibadullina E.M., Nizameev I.R., Sudakov I.A., Vyshtakalyuk A.B., Voloshina A.D., Kadirov M.K., Petrov K.A., Burilov A.R., Bukharov S.V., Zakharova L.Y., Delivery nanosystems based on sterically hindered phenol derivatives containing a quaternary ammonium moiety: Synthesis, cholinesterase inhibition and antioxidant activity, Chem. Biol. Interact. 2019, 310, 108753. doi:10.1016/j.cbi.2019.108753.
2. Pashirova T.N., Zhukova N.A., Lukashenko S.S., Valeeva F.G., Burilova E.A., Sapunova A.S., Voloshina A.D., Mirgorodskaya A.B., Zakharova L.Y., Sinyashin O.G., Mamedov V.A., Multi-targeted approach by 2-benzimidazolylquinoxalines-loaded cationic arginine liposomes against сervical cancer cells in vitro, Colloids Surf. B Biointerfaces. 2019, 178, 317-328, doi:10.1016/j.colsurfb.2019.03.021.
3. Pashirova T.N., Bogdanov A.V., Zaripova I.F., Burilova E.A., Vandyukov A.E., Sapunova A.S., Vandyukova I.I., Voloshina A.D., Mironov V.F., Zakharova L.Ya., Tunable amphiphilic π-systems based on isatin derivatives containing a quaternary ammonium moiety: The role of alkyl chain length in biological activity, J. Mol. Liq. 2019, 290, 111220, doi:10.1016/j.molliq.2019.111220.
4. Pashirova T.N., Burilova E.A., Lukashenko S.S., Gaysin N.K., Gnezdilov O.I., Sapunova A.S., Fernandes A.R., Voloshina A.D., Souto E.B., Zhiltsova E.P., Zakharova L.Ya., Nontoxic antimicrobial micellar systems based on mono- and dicationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships, J. Mol. Liq., 2019, 112062, doi:10.1016/j.molliq.2019.112062.
5. Zueva I., Dias J., Lushchekina S., Semenov V., Mukhamedyarov M., Pashirova T., Babaev V., Nachon F., Petrova N., Nurullin L., Zakharova L., Ilyin V., Masson P., Petrov K., New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease, Neuropharmacology, 2019, 155, 131-141. doi:10.1016/j.neuropharm.2019.05.025.
6. Silva A.M., Martins-Gomes C., Coutinho T.E., Fangueiro J.F., Sanchez-Lopez E., Pashirova T.N., Andreani T., Souto E.B., Soft cationic nanoparticles for drug delivery: production and cytotoxicity of solid lipid nanoparticles (SLNs), Applied sciences basel., 2019. 9(20), 4438. doi:10.3390/app9204438.

2018

1. Pashirova T.N., Braïki A., Zueva I.V., Petrov K.A., Babaev V.M., Burilova E.A., Samarkina D.A., Rizvanov I.Kh., Souto E.B., Jean L., Renard P.-Y., Masson P., Zakharova L.Ya., Sinyashin O.G., Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection, J. Controlled Release, 2018, 290, 102–111. doi:10.1016/j.jconrel.2018.10.010.
2. Zhiltsova E.P., Pashirova T.N., Ibatullina M.R., Lukashenko S.S., Gubaidullin A.T., Islamov D.R., Kataeva O.N., Kutyreva M.P., Zakharova L.Ya., New surfactant-copper(II) complex based on 1,4-diazabicyclo[2.2.2]octane amphiphile. Crystal structure determination, self-assembly and functional activity, Phys.Chem.Chem.Phys., 2018, 20 (18), 12688-12699. doi:10.1039/C8CP01954A.
3. Pashirova T.N., Zueva I.V., Petrov K.A., Lukashenko S.S., Nizameev I.R., Kulik N.V., Voloshina A.D., Almasy L., Kadirov M.K., Masson P., Souto E.B., Zakharova L.Y., Sinyashin O.G., Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model, Colloids Surf B Biointerfaces, 2018, 171, 358-367, doi:I:10.1016/j.colsurfb.2018.07.049.
4. Burilova E.A., Pashirova T.N., Lukashenko S.S., Sapunova A.S., Voloshina A.D., Zhiltsova E.P., Campos J.R., Souto E.B., Zakharova L.Ya., Synthesis, biological evaluation and structure-activity relationships of self-assembled and solubilization properties of amphiphilic quaternary ammonium derivatives of quinuclidine, J. Mol. Liq., 2018, 272, 722-730, doi:10.1016/j.molliq.2018.10.008.

Coordination and participation in scientific projects:
 

Russian Science Foundation

1. № 20-14-00155 «Cholinesterases as active components in nanoreactors for OP detoxification. Interactions with pharmacological ligands» (participant)
2. № 19-73-30012 «Development of supramolecular strategies for the fabrication of lipid and hybrid nanocontainers with functions of targeting and ability of overcoming of biological barriers for the purpose of increase in efficacy of drugs» (participant)
3. № 17-23-00005 «Development of new methods for the synthesis of bi-, tri- and tetracyclic compounds of the heterocyclic series, the creation of nano-sized water-soluble structures on their basis and prospects for biomedical use» (participant)
4. № 14-23-00073 «Development of new methods for the synthesis of bi-, tri- and tetracyclic compounds of the heterocyclic series, the creation of nano-sized water-soluble structures on their basis and prospects for biomedical use» (participant)
5. Russian Foundation for Basic Research
6. № 18-43-160015 «Amphiphilic polyfunctional nanosystems to control the solubilization of medicinal compounds, the stability of dispersions and wetting of biosurfaces» (participant)
7. № 18-03-00591 «Supramolecular nanocontainer design strategies: non-covalent modification of lipid and mineral carriers by amphiphilic molecules and polyions» (participant)
8. № 15-03-05434 «Supramolecular systems based on polymerizing and complexing amphiphiles: multifactorial control of self-organization and functional activity» (participant)
9. № 15-43-02490 «Microheterogeneous solutions of amphiphiles modified with electrolytes and polyelectrolytes. Self-organization and rheological properties» (participant)
10. № 13-03-97075 «New macrocyclic compounds with polyphenolic or terpenoid fragments. Synthesis, properties and biomimetic systems based on them» (participant)
11. № 12-03-31140 for young scientists «рН-Sensitive non-covalent complexes of calix [4] resorcinarene-surfactant for the competitive encapsulation of organic guests» (coordination)

Grant of the President of the Russian Federation for state support of young Russian scientists МК-2332.2009.3 «Supramolecular systems based on new geminal cationic surfactants exhibiting micelle-forming, liquid-crystalline and catalytic properties» (coordination)

 

Editorial Board Member of International Scientific Journals

• Associate Editor for Nanometrology Frontiers in Nanotechnology https://loop.frontiersin.org/people/2046803/overview
• Guest Editor of Special Issue “Application of Lipid Nanoparticles in Drug and Gene Delivery” Nanomaterials (MDPI). https://www.mdpi.com/journal/nanomaterials/special_issues/9Z72H72T7T

Member of Reviewers Board of International Scientific Journals

• Nanomedicine (Elsevier),
• Acta Biomaterialia (Elsevier),
• Chemical Communication (RSC),
• International Journal of Pharmaceutics (Elsevier),
• Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier),
• Molecules (MDPI), Bioengineering (MDPI), Nanomaterials (MDPI),
• International Journal of Nanomedicine (Dove Medical Press),
• Materials Today Chemistry (Elsevier),
• J Microincapsulation (Taylor & Francis),
• Molecular Pharmaceutics (ACS),
• European Journal of Pharmaceutical Sciences (Elsevier)

Supervising dissertations and theses

• Master students: 8
• Bachelor: 4