Паширова Татьяна Никандровна / Tatiana Pashirova

Researcher ID (WOS): E-6484-2014
Author id (Scopus): 6507468049
ORCID: 0000-0002-2001-1570
H-index: 22 (Scopus)
Degree: PhD in Physical Chemistry

Research interests: supramolecular chemistry, medicinal chemistry, drug delivery systems, solid lipid nanoparticles, liposomes, nanoreactors, colloidal systems, micellar catalysis.

Position
2001-Present time — Senior research fellow of the A.E. Arbuzov Institute of Organic and Physical Chemistry of the Russian Academy of Sciences, Kazan, Russian Federation

Education
2012 — Post-Doctoral Scholar at the Faculty of Health Sciences of University Fernando Pessoa, Portugal, Health Doctorate Program in the area of Biopharmaceutical Chemistry under the supervision of the Prof. Eliana B. Souto on Lipid nanoparticulates for hydrophylic peptides
2001-2005 – Ph. D. in Physical Chemistry, PhD Thesis entitled: ‘Supramolecular catalytic systems based on derivatives calix[4]resorcinarenes, phenols, their metalcomplexes and surfactants’ (A.E. Arbuzov Institute of Organic and Physical Chemistry of the Russian Academy of Sciences, Kazan, Russian Federation
1999-2001 – Master`s Degree, Kazan State Technological University, Faculty of Chemical Engineering and Technology, Kazan, Russian Federation
1995-1999 – Bachelor`s Degree, Kazan State Technological University, Faculty of Chemical Engineering and Technology, Kazan, Russian Federation
Additional education
1999-2001 – Pedagogy, Kazan State Technological University, Kazan, Russian Federation

Publications:The full list consists of 130 publications

Chapters in books:
Pashirova T.N., Afonso A.B., Terekhova N.V., Kamalov M.I., Masson P., Souto E.B., Chapter Nanogels for drug delivery: physicochemical properties, biological behavior, and in vivo applications in book Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications, Ed. Santana M.H., Souto E.B., Shegokar R., Academic Press, 2023, Elsevier Inc., P.95-131. ISBN: 978-0-323-90471-1, https://doi.org/10.1016/B978-0-323-90471-1.00005-0.
Pashirova T.N., Fernandes A.R., Sanchez-Lopez E., Garcia M.L., Silva A.M., Zakharova L.Ya., Souto E.B., Chapter 5 — Polymer nanogels: Fabrication, structural behavior, and biological applications, in Theory and Applications of Nonparenteral Nanomedicines, Academic Press, 2021, Pages 97-111. https://doi.org/10.1016/B978-0-12-820466-5.00005-3
Zakharova L.Y., Pashirova T.N., Fernandes A.R., Doktorovova S., Martins-Gomes C., Silva A.M., Souto E.B., Chapter 14: Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology, in Organic Materials as Smart Nanocarriers for Drug Delivery, Ed. A.M. Grumezescu, 2018, Elsevier, 601-618. https://doi.org/10.1016/B978-0-12-813663-8.00014-2
Zakharova L., Pashirova T., Kashapov R., Gabdrakhmanov D., Sinyashin O., Chapter 24: Drug delivery mediated by confined nanosystems: structure-activity relations and factors responsible for the efficacy of formulations, in Nanostructures for Drug Delivery, Eds. E. Andronescu, A. Grumezescu, 2017, William Andrew, 749-806. https://doi.org/10.1016/B978-0-323-46143-6.00024-5.
Zakharova L., Mirgorodskaya A., Gaynanova G., Kashapov R., Pashirova T., Vasilieva E., Zuev Y., Synyashin O., Supramolecular strategy of the encapsulation of low molecular weight food ingredients, in Encapsulations, Ed. A.M. Grumezescu, 2016, Academic Press, 924, 295-362. 10.1016/B978-0-12-804307-3.00008-9.

Reviews:
Shaihutdinova Z.M., Pashirova T.N., Masson P. Slow-binding inhibitors of enzymes: kinetic characteristics and pharmacological interest, Biomed Khim, 2025, 71(2), 81-94. 10.18097/PBMCR1536 Masson P., Pashirova T. Affinity Electrophoresis of Proteins for Determination of Ligand Affinity and Exploration of Binding Sites, Int. J. Mol. Sci. 2025, 26(7), 3409; https://doi.org/10.3390/ijms26073409
Pashirova T., Salah-Tazdaït R., Tazdaït D., Masson P., Applications of Microbial Organophosphate-Degrading Enzymes to Detoxification of Organophosphorous Compounds for Medical Countermeasures against Poisoning and Environmental Remediation, Int. J. Mol. Sci. 2024, 25(14), 7822; https://doi.org/10.3390/ijms25147822
Varfolomeev S.D., Švedas V., Efremenko E.N., Egorov A.M., Khrenova M.G., Tishkov V.I. et al. Biocatalysis: modern problems and applications, Russian Chemical Reviews, 2024, 93 (12) RCR5144 https://doi.org/10.59761/RCR5144
Pashirova T.N., Nemtarev A.V., Souto E.B., Mironov V.F. Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application, Russian Chemical Reviews, 2023, 92 (10), RCR5095. https://doi.org/10.59761/RCR5095
Pashirova T.N., Shaikhutdinova Z.M., Mironov V.F., Bogdanov A.V. Ammonium Amphiphiles Based on Natural Compounds: Design, Synthesis, Properties, and Biomedical Applications. A Review, Dokl Chem, 2023, 509, 71–88. https://doi.org/10.1134/S0012500823700179
Pashirova T.N., Shaihutdinova Z.M., Mironov V.F., Masson P. Biomedical Nanosystems for in vivo Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots, 2023, 15 (1) 4-12. https://doi.org/10.32607/actanaturae.15681
Pashirova T.N., Shaihutdinova Z.M., Souto E.B., Masson P., Mironov V.F. Nanoparticle Concentration as an Important Parameter for Characterization of Dispersion and Its Applications in Biomedicine, Colloid J., 2023, 85, 770–781. https://doi.org/10.1134/S1061933X23600720
Pashirovа T.N., Bogdanov A., Masson P. Therapeutic nanoreactors for detoxification of xenobiotics: Concepts, challenges and biotechnological trends with special emphasis to organophosphate bioscavenging, Chem. Biol. Interact., 2021, 346, 109577, https://doi.org/10.1016/j.cbi.2021.109577
Bjerk T.R, Severino P., Jain S., Marques C., Silva A.M, Pashirova T., Souto E.B, Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology, Bioengineering (Basel). 2021, 8(8), 115, https://doi.org/10.3390/bioengineering8080115
Zakharova L.Y., Pashirova T.N., Doktorovova S., Fernandes A.R., Sanchez-Lopez E., Silva A.M., Souto S.B., Souto E.B., Cationic surfactants: self-Assembly, structure-activity correlation and their biological applications, Int. J. Mol. Sci. 2019, 20(22). pii: E5534. https://doi.org/10.3390/ijms20225534
Souto E.B., Souto S.B., Campos J.R., Severino P., Pashirova T.N., Zakharova L.Y., Silva A.M., Durazzo A., Lucarini M., Izzo A.A., Santini A., Nanoparticle delivery systems in the treatment of diabetes complications, Molecules, 2019, 24, 4209. https://doi.org/10.3390/molecules24234209

Patents:
Liposomal form of Abies Sibirica resin for non-invasive delivery of the biologically active substance of Abies Sibirica oleoresin to brain, which has antioxidant, cytotoxic activity against cervical cancer cells, and method for its production, Sinyashin K.O., Zakharova L.Ya., Pashirova T.N., Petrov K.A., Voloshina A.D., Vyshtakalyuk A.B., Rizvanov I.Kh., Babaev V.M., Maganova F.I. Patent № RU 2757873 C2, 22.10.2021. Application № 2019139529 from 03.12.2019.

Articles (Last 5 years):
2025
Pashirova T., Tatarinov D., Shaihutdinova Z., Malanyeva A., Vasileva O., Rogov A., Evtjugin V., Nemtarev A., Chabrière E., Jacquet P., Daudé D. Masson P. Enzyme-containing double layer polymersomes coated by erythrocytes as a biomimetic nanoscavengers for in vivo protection from toxicants, Mater. Adv., 2025, 6(24), 9516-9527. https://doi.org/10.1039/d5ma00894h
Shaihutdinova Z.M., Vandyukov A.E., Lushchekina S.V., Mironov V.F., Bukharov S.V., Tagasheva R.G., Bogdanov A.V., Arsenyev M.V., Masson P., Pashirova T.N. Amphiphilic ammonium acylhydrazones on the base of sterically-hindered catechol: Synthesis, self-assembly, reversible inhibition of butyrylcholinesterase and structure-activity relationships, J. Mol. Liq, 2025, 437. Art. No. 128360. https://doi.org/10.1016/j.molliq.2025.128360
Pashirova T.N., Tatarinov D.A., Gabova M.V., Batasheva S.N., Kuryakov V.N., Shaihutdinova Z.M., Mironov V.F., Masson P. Creation of Efficient Biocatalytic Nanoscavengers for Detoxification of Organophosphorus Compounds: Influence of Nanoparticle Type, Colloid Journal. 2025. V. 87. No. 6. P. 970–980, 10.1134/S1061933X25601374.
Shaihutdinova Z.M., Sapunova A.S., Salakhieva D.V., Pashirova T.N., Voloshina A.D, Bogdanov A.V. Micelle-Forming and Antimicrobial Properties of a Series of Bis-Quaternized Ammonium Compounds Based on DABCO Derivatives, Colloid Journal. 2025, V. 87, P. 246–254, https://doi.org/10.1134/S1061933X25600010
2024
Fetin P.A., Zorin I.M., Shaihutdinova Z.M., Masson P. Pashirova T.N. Polystyrene–Poly(acrylic acid) Block Copolymers for Encapsulation of Butyrylcholinesterase into Injectable Nanoreactors, Biomolecules 2024, 14, 1555. https://doi.org/10.3390/biom14121555
Pashirova T.N., Nemtarev A.V., Buzyurova D.N., Shaihutdinova Z.M., Dimukhametov M.N., Babaev V.M., Voloshina A.D., Mironov V.F., Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro, Nanomaterials, 2024, 14(1), 55. https://doi.org/10.3390/nano14010055
Zoughaib M., Pashirova T.N., Nikolaeva V., Kamalov M., Nakhmetova F.; Salakhieva D.V., Abdullin T.I. Anticancer and Chemosensitizing Effects of Menadione-Containing Peptide-Targeted Solid Lipid Nanoparti, Journal of Pharmaceutical Sciences, 2024, https://doi.org/10.1016/j.xphs.2024.03.009
Pashirova T.N., Mustakimova L.V, Nizameev I.R., Saitova A., Vandyukov A.E., Sapunova A.S., Kadirov M.K., Voloshina A.D., Sinyashin O.G., Mamedov V.A., Hybrid arginine-modified phospholipid nanotherapeutics based on multitarget quinoxalin-2-ones for cancer-cells delivery, J. Mol. Liq., 2024, 407, 125149, https://doi.org/10.1016/j.molliq.2024.125149 Q1
Pashirova T., Shaihutdinova Z., Tatarinov D., Titova A., Malanyeva A., Vasileva O., Gabdurakhmanov K., Dudnikov S., Schopfer L.M., Lockridge O., Masson P., Pharmacokinetics and fate of free and encapsulated IRD800CW-labelled human BChE intravenously administered in mice, Int. J. Biol. Macromol., 2024, 282, Part 6, 137305, https://doi.org/10.1016/j.ijbiomac.2024.137305
Bogdanov A.V., Voloshina A.D., Il’in A.V., Kadomtseva M.E., Pashirova T.N., Shaihutdinova Z.M., Mironov V.F., Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity // Russian Journal of General Chemistry. 2024. Vol. 94, No. 11, P. 3099–3103 10.1134/S1070363224110331
2023
Pashirova T., Shaihutdinova Z., Tatarinov D., Mansurova M., Kazakova R., Bogdanov A., Daudé D., Jacquet P., Chabrière E., Akhunzianov A.A, Miftakhova R.R., Masson P. Tuning the Envelope Structure of Enzyme Nanoreactors for In Vivo Detoxification of Organophosphates, Int. J. Mol. Sci, 2023, 24(21), 15756, 10.3390/ijms242115756
Mironov V.F.,Dimukhametov M.N., Nemtarev A.V., Pashirova T.N., Tsepaeva O.V., Voloshina A.D., Vyshtakalyuk A.B., Litvinov I.A., Lyubina A.P., Sapunova A.S., Abramova D.F., Zobov V.V., Novel Mitochondria-Targeted Amphiphilic Aminophospho-nium Salts and Lipids Nanoparticles: Synthesis, Antitumor Activity and Toxicity, Nanomaterials, 2023, 13(21), 2840; 10.3390/nano13212840
Mukhametgalieva A.R., Nemtarev A.V., Sykaev V.V., Pashirova T.N., Masson P. Activation / Inhibition of cholinesterases by excess substrate: interpretation of the phenomenological «b» factor in steady-state rate equation, Int. J. Mol. Sci. 2023. Vol. 24. Art. No. 10472, 10.3390/ijms241310472
Tsepaeva O.V., Nemtarev A.V., Pashirova T.N., Khokhlachev M.V., Lyubina A.P., Amerkhanova S.K., Voloshina A.D., Mironov V.F. Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, targeted cancer-cells delivery, RSC Med. Chem., 2023, 14(3), 454-469, 10.1039/D2MD00363E
2022
Pashirova T.N., Shaihutdinova Z., Mansurova M., Kazakova R., Shambazova D., Bogdanov A., Tatarinov D., Daudé D., Jacquet P., Chabrière E., Masson P. Enzyme Nanoreactor for In Vivo Detoxification of Organophosphates, ACS Appl Mater Interfaces, 2022, 14(17), 19241-19252, 10.1021/acsami.2c03210.
Pashirova T.N., Shaihutdinova Z.M., Vandyukov A.E., Lyubina A.P., Amerhanova S.K., Voloshina A.D., Samorodov A.V., Souto E.B., Mironov V.F., Bogdanov A.V., Synthesis and structure-activity-toxicity relationships of DABCO-containing ammonium amphiphiles based on natural isatin scaffold, J. Mol. Liq., 2022, 365, 120217. 10.1016/j.molliq.2022.120217.
Shaihutdinova Z., Pashirova T.N., Masson P. Kinetic Processes in Enzymatic Nanoreactors for In Vivo Detoxification, Biomedicines, 2022, 10(4), 784, 10.3390/biomedicines10040784.
2021
Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: synthesis, structure, and biological properties, Molecules, 2021, 26(21), 6350. 10.3390/molecules26216350
2020
Pashirova T.N., Sapunova A.S., Lukashenko S.S., Burilova E.A., Lubina A.P., Shaihutdinova Z.M., Gerasimova T.P., Kovalenko V.I., Voloshina A.D., Souto E.B., Zakharova L.Ya, Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations, Int J Pharm, 2020, 575, 118953. 10.1016/j.ijpharm.2019.118953.
Burilova E.A, Pashirova T.N, Zueva I.V, Gibadullina EM, Lushchekina SV, Sapunova AS, Kayumova RM, Rogov AM, Evtjugin VG, Sudakov IA, Vyshtakalyuk AB, Voloshina AD, Bukharov SV, Burilov AR, Petrov K.A, Zakharova L.Ya, Sinyashin O.G., Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer’s disease via an intranasal route, Nanoscale, 2020, 12(25), 13757-13770. 10.1039/d0nr04037a.
Buzyurova D.N., Pashirova T.N., Zueva I.V., Burilova E.A., Shaihutdinova Z.M., Rizvanov I.Kh., Babaev V.M., Petrov K.A., Souto E.B. Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat, Toxicology, 2020, 444, 152578, 10.1016/j.tox.2020.152578.
Pashirova T.N., Fetin P.A., Lezov A.A., Kadnikov M.V., Valeeva F.G., Burilova E.A., Bilibin A.Yu., Zorin I.M., Self‐Assembled Quaternary Ammonium‐Containing Comb‐Like Polyelectrolytes for the Hydrolysis of Organophosphorous Esters: Effect of Head Groups and Counter‐Ions, ChemPlusChem, 2020, 85, 8, 1939-1948, 10.1002/cplu.202000417.
do Nascimento M.F, Cardoso J.C., Santos T.S., Tavares L.A., Pashirova T.N., Severino P., Souto E.B., de Albuquerque-Junior R.L.C., Development and characterization of biointeractive gelatin wound dressing based on extract of punica granatum linn, Pharmaceutics, 2020, 12, 1204; 10.3390/pharmaceutics12121204.
Terekhova N.V., Tatarinov D.A., Shaihutdinova Z.M., Pashirova T.N., Lyubina A.P., Voloshina A.D., Sapunova A.S., Zakharova L.Ya, Mironov V.F, Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action, Bioorg. Med. Chem. Lett., 2020, 30(13), 127234. 10.1016/j.bmcl.2020.127234.

Coordination and participation in scientific projects:
RSF № 25-23-00617 Development of the new highly effective forms of the phosphonic acids glycidyl esters and their derivatives based on natural lipids for the treatment of skin cancer (Coordination)
RSF № 20-14-00155-P «Cholinesterases as active components in nanoreactors for OP detoxification. Interactions with pharmacological ligands» (main participant)
RSF № 20-14-00155 «Cholinesterases as active components in nanoreactors for OP detoxification. Interactions with pharmacological ligands» (main participant)
RSF № 19-73-30012 «Development of supramolecular strategies for the fabrication of lipid and hybrid nanocontainers with functions of targeting and ability of overcoming of biological barriers for the purpose of increase in efficacy of drugs». (main participant)
RSF № 17-23-00005 «Development of new methods for the synthesis of bi-, tri- and tetracyclic compounds of the heterocyclic series, the creation of nano-sized water-soluble structures on their basis and prospects for biomedical use». (participant)
RSF № 14-23-00073 «Development of new methods for the synthesis of bi-, tri- and tetracyclic compounds of the heterocyclic series, the creation of nano-sized water-soluble structures on their basis and prospects for biomedical use». (participant)
RFBR № 18-43-160015 «Amphiphilic polyfunctional nanosystems to control the solubilization of medicinal compounds, the stability of dispersions and wetting of biosurfaces». (participant)
RFBR № 18-03-00591 «Supramolecular nanocontainer design strategies: non-covalent modification of lipid and mineral carriers by amphiphilic molecules and polyions» (participant)
RFBR № 15-03-05434 «Supramolecular systems based on polymerizing and complexing amphiphiles: multifactorial control of self-organization and functional activity». (participant)
RFBR № 15-43-02490 «Microheterogeneous solutions of amphiphiles modified with electrolytes and polyelectrolytes. Self-organization and rheological properties». (participant)
RFBR № 13-03-97075 «New macrocyclic compounds with polyphenolic or terpenoid fragments. Synthesis, properties and biomimetic systems based on them». (participant)
RFBR № 12-03-31140 for young scientists «рН-Sensitive non-covalent complexes of calix [4] resorcinarene-surfactant for the competitive encapsulation of organic guests». (Coordination)
МК-2332.2009.3 Grant of the President of the Russian Federation for state support of young Russian scientists «Supramolecular systems based on new geminal cationic surfactants exhibiting micelle-forming, liquid-crystalline and catalytic properties» (Coordination)

Awards, honorary titles
National Award for Women in Science and Technology (KOLBA) in the Chemistry (2023)
https://vestniknews.ru/novosti/13270-v-moskve-proshel-forum-zhenshchiny-v-nauke-i-tekhnologiyakh-2023-i-vruchenie-premii-kolba.html

Editorial Board Member of International Scientific Journals
Associate Editor of Nanometrology, Frontiers in Nanotechnology (Frontiers) https://loop.frontiersin.org/people/2046803/overview
Guest Editor of Special Issue “Application of Lipid Nanoparticles in Drug and Gene Delivery” Nanomaterials (MDPI). https://www.mdpi.com/journal/nanomaterials/special_issues/9Z72H72T7T

Media publications
Супрамолекулярная химия – наука, которую я люблю (14.03.2024) https://designersfromrussia.ru/supramolekulyarnaya-himiya-nauka-kotoruyu-ya-lyublyu/
Женщины в науке: Татьяна Паширова. Супрамолекулярная химия – наука, которую я люблю (18.03.2024) https://vestniknews.ru/novosti/14559-zhenshchiny-v-nauke-tatyana-pashirova-supramolekulyarnaya-khimiya-nauka-kotoruyu-ya-lyublyu.html